New clinical study on HMOs
Overview
For the first time 5 HMOs (Human Milk Oligosaccharides) that combine all 3 major HMO categories will be available in an infant formula. The first ever clinical study with a unique 5HMO blend has shown that the formula is safe and supports age-appropriate growth similar to breastfed infants.1
The 5 HMOs in SMA® ADVANCED FORMULAS
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Are among the most abundant, quantitatively accounting for more than 40% of the 20 HMOs generally measured in breastmilk.2-6
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Together they represent the three HMO families.7
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Are uniquely combined in proportions based on HMO ratios in breast milk.8
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Are structurally identical to HMOs in breast milk.9-18
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Are generally recognised as safe by the US FDA (GRAS) and evaluated as safe by EFSA.9-18
HMOs and gut development article
Includes a 5 minute video and downloadable resources.
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Bosheva, M. et al. Frontiers in nutrition, 9, 920362. https://doi.org/10.3389/fnut.2022.920362
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Samuel TM, et al. Sci Rep 2019;9(1):1-10;
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Austin S, et al. Nutrients 2016:8;8(6);
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Austin S, et al. Nutrients 2019;11(6):1282;
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Sprenger N, et al. Eur J Nutr 2017;56(3):1293-1301;
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Lefebvre G, et al. Front Nutr 2020;7:574459;
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Donovan SM, et al. Ann Nutr Metab 2016;69 (Suppl 2):42-51;
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Nestlé Internal data;
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2FL/DFL: Response letter to GRAS notice GRN000815, August 2019;
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LNT: Response letter to GRAS notice GRN000833, April 2020;
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3SL: Response letter to GRAS notice GRN000880, April 2020;
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6SL: Response letter to GRAS notice GRN000881, April 2020;
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EFSA Journal 2019;17(6):5717;
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Commission implementing regulation (EU) 2019/1979 of 26 November 2019;
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EFSA Journal 2020;18(5):6098;
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EFSA Journal 2020;18(5):6097;
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Commission implementing regulation (EU) 2020/484 of 2 April 2020;
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EFSA Journal 2019;17(12):5907;
IMPORTANT NOTICE:
We believe that breastfeeding is the ideal nutritional start for babies and we fully support the World Health Organization’s recommendation of exclusive breastfeeding for the first six months of life followed by the introduction of adequate nutritious complementary foods along with continued breastfeeding up to two years of age. We also recognise that breastfeeding is not always an option for parents. We recommend that healthcare professionals inform parents about the advantages of breastfeeding. If parents choose not to breastfeed, healthcare professionals should inform parents that such a decision can be difficult to reverse and that the introduction of partial bottle-feeding will reduce the supply of breast milk. Parents should consider the social and financial implications of the use of infant formula. As babies grow at different rates, healthcare professionals should advise on the appropriate time for a baby to begin eating complementary foods. Infant formula and complementary foods should always be prepared, used and stored as instructed on the label in order to avoid risks to a baby’s health. The product should be used only on the advice of independent persons having qualifications in medicine, nutrition, pharmacy, or other professionals responsible for maternal and child care.